The global gene expression market is estimated to reach USD 11.3 billion by 2025. Market is also expected to grow at a decent rate over the forecast period driven by rising number of cancer patients, facilities for financial funding, decreased cost of sequencing, and high concentration on research & development. In emerging economies, the industry offers advantageous opportunities for growth with rising concentration on adoption and precision as well as personalization in medicines. However, currency devaluation in developing economies and initial capital investment of different instruments are considered as restraint as well as challenge for the industry.
The gene expression is a set of steps for a functional genetic code product occur in the synthesis, with the support of the data coded on genes. The process is prominent in multi cellular organisms as well as bacteria such as eukaryotes or prokaryotes, which ensure the creation of machinery macro molecular of their life.
In context with the consumables of gene expressions, the industry is classified into DNA chips and reagents. The segment of reagent held the largest revenue share of consumables in the industry. This segment is anticipated to witness high growth influenced by increasing number of service center for sequencing, research & development with financial funding, and rising installation number of analysis instruments.
The overall market can be segmented by technologies into Northern Blotting, SAGE, Micro array, DNA, NGS, and PCR. The NGS technological segment is considered to be the rapidly growing sector. However, the PCR technology held the largest revenue share over the forecast period. The rapid growth of NGS technology is influenced by rise in large scale gene expression demand, technological advancement & improvised throughput & speed, wide spectrum of applications, and in depth knowledge of sequencing DNA.
The services offered by this industry are classified as bio informatics solutions and profiling services. Profiling services of gene expressions occupy the largest industry share. The profiling services provide essential insights in terms of personalized medicine, determining drug, and enhanced diagnosis of disease. Aforementioned factor would drive the demand for profiling services over the forecast period.
The genetic code expression includes translation and transcription process. The translation process protein from RNA is a sequence occurs in the protein-based synthesis on coding genes data. The transcription from DNA to RNA can be described to the creation of coples RNA of DNA with the support of the RNA enzyme polymerase. The regulations of genetic code refer to its functions, renders cell control through structure, versatility & differentiation of cellular substance, and morphogenesis. The alteration in the overall process can be possible with such as modification of proteins after translation process, and splicing of RNA.
The profiling primarily refers to the set of step used to measure the expression of numerous genetic codes in order to determine the functions related to cellular. This process can be helpful to determine the differences in molecular base of phenotypic and offers the target GE selection for research purpose. There are various techniques used for this analysis such as transcriptase sequencing, analysis of micro array, PCR based real time profiling, and serial analysis of GE among others.
However, reagents are the chemical substances required in the studies undertaken to identify the pattern. Traditionally available reagents kits include hybridization, Taq Man assay, sample labeling and amplification, sample preparation and isolation and other significant kits.
The North America industry is estimated to hold the largest share, followed by Asia Pacific and Europe. The Asia Pacific region is estimated for the rapid growth over the forecast period. The growth in this region is influenced by increasing gene test popularity, government concern to improve healthcare with laws & regulation, and rising agriculture research activity.
The vital factors influencing the growth and contribution of aforementioned region include development of databases, increasing R & D, and continuous advancement & innovation in technology across the world. Rising initial funding and investment for research in genetic by government as well as the growing awareness & popularity of gene expressions is expected to shift demand. Recently, classified systems of GE have determined a cancer subtype aggressive colon with features like mesenchymal, which ensures EMT of tumor cells.
Some of the major players competing in this industry are Agllent Technologies, Bio Rad Laboratories, Thermo Fisher Scientific, Qiagen N.V., Illunia Inc., Affymetrix Inc., and other prominent players. High initial cost for instruments as well as lack of expertise & skilled technician would hinder the growth. However, with numerous advantages and rising interest for precise medicines, the growth & scope of new studies would influence the adoption of reagents.
Process Outlook (Revenue, USD Million; 2014 - 2025)
• Sample Collection
• cDNA synthesis & conversion
• PCR Analysis
• Data analysis & interpretation
Product Outlook (Revenue, USD Million; 2014 - 2025)
• Kits & Reagents
• DNA Chips
Capacity Outlook (Revenue, USD Million; 2014 - 2025)
• Low- to Mid- Plex
Technique Category Outlook (Revenue, USD Million; 2014 - 2025)
• RNA Expression
• Northern Blotting
• DNA Microarrays
• PCR Techniques
• Promoter Analysis
• In vitro Transcription/Nuclear Run-On Assays
• Gel Shift Assays
• Chromatin Immunoprecipitation (ChIP)
• Protein Expression & Posttranslational Modification Analysis
• Western Blotting
• 2-D Gel Electrophoresis
• Mass Spectrometry
Application Outlook (Revenue, USD Million; 2014 - 2025)
• Drug Discovery & Development
• Clinical Diagnostics
• Biotechnology & Microbiology
Regional Outlook (Revenue, USD Million; 2014 - 2025)
• North America
• Asia Pacific
• Latin America
• Middle East and Africa (MEA)
• South Africa
Research Support Specialist, USA